.NET Bio 1.1 is a minor release with fixes discovered after the release of .NET Bio 1.01. There are some significant changes to the reference algorithms - (Needleman-Wunsch) and (Smith-Waterman) however.
Also there has been significant changes to Padena
1) The minimum kmer length is now recommended to be 13.
2) KMERS are not forced to be odd but users are prompted when using PADENA that is what they desire in order to avoid palindromes. If you don't supply a KMER an odd one is supplied.
These items are detailed in the release notes.